Your work is incredibly relevant and it is NEEDED. I don’t comment often (although I read your work and appreciate it a lot), this really prompted me to say something. I’m not a high level medical professional but I work as a Paramedic in the Boston area (and am in several of the well known hospitals frequently). I have been for a decade now. The alarming uptick in thrombocytopenia, heart disease, clotting disorders, cancer, pulmonary issues, autoimmune disorders, etc... is truly alarming. I work emergency 911 calls, but have a substantial amount of experience with transferring acutely (and chronically) ill patients from hospital to hospital, and sometimes to rehabs, and even hospice. I steered clear of the Covid “vaccines” (me and my family) and have paid close attention to what is truly happening concerning the repercussions and negative, sometimes (or more) deadly consequences of the untested/unproven mRNA jabs. I see it firsthand. I want to thank you for your incredible work, and I encourage and implore you to please keep informing us of these statistics. This is not only a physical war we are in, but a spiritual one at its core.
God Bless you, sir. I will be in prayer that God continues to strengthen you with every article and post you publish. This type of information (and your “opinions”) are what is needed to be disseminated. I pass it along because it’s vital in order to stop this tyranny and intentional destruction of precious life. I pray we will overcome this evil with Christ’s strength and help. I am hopeful and committed to this fight along side you and many others. Thank you!
Thanks much. I have a contact who was trying to get the call logs for 9-1-1 in a county in NY near NYC. It never happened. If only I could get those, I could really provide even more of a foundation. People are weird around Massachusetts. I've told many people about individual child deaths and young adults. They just smile and sometimes say, "Well, some are going to die, but it saved so many people." Ughh.
It’s unbelievable, John! I’m not a native of MA (although my mother is from here and my kids were born here) I am keenly aware of how misled so many are in this state. It’s as if they have genuinely bought into the Covid “narrative” (to include my own father, brother, sister, and my mother-in-law) that those who are beyond cognitive dissonance, but truly blinded by a psychology of “mass psychosis” just go along. No questions asked. I want more information on the stats you mention, desperately, but it’s going to take a seriously concerted effort on all of us who know the Truth to continue to bring it forth to the misinformed. And, in my humble opinion, taken advantage of in their mental/spiritual weakness. It’s sick. Please keep up your amazing work!!
These people need some kind of response that will blow their stupid ideas right out of their heads... I'll keep trying to find that perfect Word Bomb...
Sending you a GIANT hug-- KEEP GOING! You're fantastic, m'dear. xo xo
John, I am a nurse and I believe your assessment of the data is important.
When a doctor speaks to their patient, they pretty much use medical terms to explain the diagnosis, quickly add a few more descriptions and thats it. A patient leaves not having any idea what the doctor just said, will remember a few simple terms and maybe attempt to look up what they think they heard.
The patient really doesn't know their diagnosis, can't understand the literature...that is if they can even find it. They certainly have no idea how to look for or interpret any data associated with covid deaths, death certificates, codes, etc which might be associated with the symptoms they are experiencing.
If a patient dares to ask their doctor if their symptoms are related to the covid injection, 99% of the time the doctor will tell them it has nothing to do with their symptoms. People are conditioned to believe their doctor, the government and MSM.
I believe the information you provide is more than your opinion. You gather all the information for us and explain it in terms we can understand. It makes sense even to those who have idea about stats, data, etc!
If we don't have your expertise and ability to translate that information to us ..what will we have? More lingo, stuff that doesn't make sense and then we don't learn.
Opinion is what MSM, fauci,fda, cdc does .. they lie and never tell the truth. Your information is so much more than an opinion. And that's my 2 cents worth!
Agree 100%!! I’m not a nurse but am in hospitals as a paramedic (I do a lot of transfer work) and hear Dr’s talk to patients, as well as read patients charts all the time. As well as, obviously, I Interact with nurses the most. That’s where I usually get the truth, or at least what’s happening on a raw level. I don’t trust these young Dr’s nowadays. Even some older, more experienced ones. It pains me to say that but it’s truly how I feel. SO many people are lied to, or at minimum, not communicated well with, which is so sad. And, easy to fix, but they don’t.
Sep 17, 2023·edited Sep 17, 2023Liked by Coquin de Chien
You went so far to state your credentials before the opinion. From there the reader can consider it or not but removing it seems problematic as it seems someone has silenced you. JMO.
Thank you John. Let's pray that the criminals are held accountable. Covid is obviously a eugenics program. David Martin makes the connection in this video:
Fascinating. The connection with thrombocytopenia, internal bleeding. I am witnessing this happening to a friend in her 80’s. She recently, (the past six months) has now had three episodes of passing blood. The most recent episode this past weekend. She is taken to hospital each time, til the bleeding stops and then sent home. Her doctors appear to be mystified. They cannot find a tumour or other cause for her bleeds. We are in the UK, so I doubt any type of scans were performed. My friend is an active 80 yr old, plays lawn bowls, bridge, walks each day to the shop for her newspaper. She has taken at least four if not five covid jabs. And yet not one doctor has mentioned thrombocytopenia to her. Instead they “think” she has diverticulitis. In all honesty, maybe it is best she not know, as there isn’t a thing she can do about it. The damage has been done. As I witness so many acquaintances suffering heart attacks, strokes, turbo cancers, severe vertigo, severe fatigue, unsteadiness, dementia post vaxxes, I can only shake my head in despair. The damage has been done.
Zinc levels are lower in patients with primary immune thrombocytopenia (https://doi.org/10.1007/s12011-022-03295-3) AND 15 experimental zinc(II) sites were identified on SARS-CoV-2 proteins through in silico approach. Since the Spike protein forms a trimer, a total of 9–12 zinc(II) ions could be bound to each complex.
It is my hypothesis that Zinc deprivation is the lowest common denominator of what is observed. p53 and ZAP (Zinc antiviral protein) are noth Zinc-dependent for example. If so this would lead, also in the affected tissues, to a down regulation of homocysteine (Hcy) re-methylation to methionine (Met) because both enzymes that catalyzed the reaction are zinc dependent: Met synthase (MS) or betaine Hcy methyltransferase (BHMT).
This would result in:
- A global decrease of the methylation processes thanks to:
o An increase S-adenosylhomocysteine (SAH) intracellular concentration (a well-known inhibitor of methyltransferase catalytic activities)
o And a decrease of S-adenosyl-l-methionine (SAM) intracellular concentration
- and an increase of the Hcy concentration.
As Hcy is a crux of two vital metabolic pathways: 1) the one-carbon cycle that provides C1 units for nucleotide and amino acid biosynthesis; and 2) the metabolism of sulfur-containing amino acids to regenerate Met or to provide cysteine (Cys), the short-, medium- and long-term health impacts could be huge. Among them,
1) Disturbances of lipid metabolism2: the decrease of the global methylation processes, include the conversion of phosphatidylethanolamine to phosphatidylcholine (PC). The decreased concentration of PC increases the maturation of the transcription factor sterol regulatory element-binding protein 1 (SREBP-1), thus increasing the expression of genes involved in fatty acid and triglyceride synthesis.
2) Down regulation of protection against oxidative stress3 by:
a. Downregulation of glutathione and taurine because SAM is an allosteric activator of cystathionine-beta-synthetase (CBS), one of the two-step Hcy transsulfuration to Cysteine enzymes.
b. Downregulation of SIRTUINS as they are zinc dependent. SIRT1-7 have broad action roles in the epigenetic regulation. They have the potential to change gene expression and pathways utilizing a mechanism of lysine deacetylation, by which they are able to modify histones or nonhistone proteins to alter structure and functionality. For example, SIRT1 protects organisms from the effects of oxidative stress by deacetylating a number of protein substrates. These include FoxOs, p53, poly-adenosine 5′-diphosphate (ADP), PGC1-α and the p65 subunit of NF-kappa Bis.
3) Abnormal DNA methylation4: DNA methylation plays a key role in maintaining chromosome stability and gene expression. The decreased methylation level of CpG islands promotes gene transcription and expression, and increased methylation levels of CpG islands reduce or silence gene expression. Normal methylation sites and the methylation degree are affected in the early stage of carcinogenesis, which primarily manifests as global gene hypomethylation and hypermethylation of individual sites, such as the promoter of tumor suppressor genes, which exhibit a low methylation or non-methylation state in normal cells. Moreover, a recent study5 highlighted the role of epigenetic modification of DNA methylation and pathways possibly involved in Immunoglobulin-G4-related disease pathogenesis.
4) Homocysteine modification in protein structure6: Homocysteine-containing proteins (through: protein homocysteinylation of lysine by L -Hcy-thiolactone ; participation in protein biosynthesis via S-nitroso-Hcy ; demethylation of protein Met residues to Hcy) lose their biological function and acquire cytotoxic, proinflammatory, proatherothrombotic, and proneuropathic properties (e.g.: free thiol form of Hcy is associated with endothelial dysfunction ; Hcy-thiolactone predicts acute myocardial infarction ; anti-N-Hcy-protein autoantibodies are elevated in stroke and coronary artery disease patients ; N-Hcy-protein are linked with atherosclerosis ; high Hcy is a risk factor for Alzheimer’s disease…)
1/ Andreini and colleagues “The zinc proteome of SARS-CoV-2” - Metallomics. 2022; 14(7): mfac047. doi: 10.1093/mtomcs/mfac047
2/ Masana and colleagues “Low HDL and high triglycerides predict COVID-19 severity” - Sci Rep. 2021 Mar 30;11(1):7217. doi: 10.1038/s41598-021-86747-5
3/ Kalous and colleagues “Mechanism of Sirt1 NAD+-dependent Protein Deacetylase Inhibition by Cysteine S-Nitrosation” - J Biol Chem. 2016 Dec 2; 291(49): 25398–25410. doi: 10.1074/jbc.M116.754655
4/ Li and colleagues “Blood-based DNA methylation signatures in cancer: A systematic review” -Biochim Biophys Acta Mol Basis Dis. 2023 Jan 1;1869(1):166583. doi: 10.1016/j.bbadis.2022.166583
5/ Wu and colleagues “Differential CpG DNA methylation of peripheral B cells, CD4+ T cells, and salivary gland tissues in IgG4-related disease” Arthritis Res Ther. 2023 Jan 7;25(1):4. DOI: 10.1186/s13075-022-02978-5
6/ Jakubowski “Homocysteine Modification in Protein Structure/Function and Human Disease” - Physiol Rev. 2019 Jan 1;99(1):555-604. doi: 10.1152/physrev.00003.2018
Very interesting theories about bowel necrosis and gastro bleeding. Shockingly similar to the symptoms seen in Sept/Oct 1917 on the USS Leviathan Spanish Flu "death" ship and for one of its famous very ill passengers on its transatlantic mini-plague death voyage right beforehand. Note the symptom reports which include "rare" nasal bleeding for the sick passengers who would likely have been overdosed with the new wonder drug aspirin, a blood anti-coagulant. Note the mass jabbing of the Tennessee regiment in 1917 within less than 2 weeks before boarding the "death" ship. The novel meningitis jab was being injected into US military personnel sent to the WW1 French trenches.
Summer of 1918, FDR representing the US Navy Secretary returned from Europe on USS Leviathan, a massive liner converted to a troop carrier. Many died of the Spanish Flu on his 11-day westbound voyage. Roosevelt became very ill with influenza and complicating pneumonia but recovered by the time the ship landed in New York.
Leviathan's next trip eastbound to Europe:
- 3,500 troops from Tennessee "inoculated and vaccinated" within 2 weeks before before sailing. Approx 9,000 troops and 2,000 crew on board. 110 taken off the ship with Spanish Flu right before sailing, many collapsed while marching to the ship and never got onboard. All portholes closed due to fears of German U-boats; hot, stifling and overcrowded.
- Day 2 enroutete, sick bay overwhelmed with men suffering symptoms of flu. Day 3, 700 more men sick and one dead.Healthy men were confined to less well ventilated quarters. Anyone aboard sick with flu very likely would have been severely over dozed with aspirin, the standard go-to wonder drug back then for Spanish Flu. That just makes getting pneumonia much easier. Crashes immune system. FDR working for the Secretary of the Navy would likely also have received all the new whiz-bang pills like aspirin and jabs such as the new meningitis jab before sailing on that ship back from France.
- Day 4, 2,000 men sick. Official Navy report states "pools of blood from severe nasal hemorrhages [a rare Spanish Flu symptom] were scattered throughout the compartments, and the attendants were powerless to escape tracking through the mess, because of the narrow passages between the bunks." Decks covered in vomit attributed to sea sickness.
- Ship docked in Brest on October 8, 1918 with 2,000 men sick with flu and pneumonia, 80 died and been buried at sea. Another report, 280 of the ill men were too weak to get off the ship and 14 more died before the end of the day. Yet another report states 91 died aboard from Spanish Flu, hundreds taken ashore in France sick. No official count how many died there from sickness caught onboard or right before boarding. Some 1,000 of the remaining patients carried via stretcher to a base camp in a convoy that stretched four miles. From the Vermont regiment alone at least 200 died of the Spanish Flu to be buried at the French port
- chills, nausea, and pain in his lower back; one legs felt weak, fever, diagnosed with bad summer cold, by evening, one leg paralyzed, other become weak; Both legs paralyzed, temperature was 102 °F, pain in legs, feet and back; legs numb then painfully sensitive to touch, "so painful that he could not stand the pressure of the bedclothes, and even the movement of the breezes across his skin caused acute distress." Could not pass urine. Hands, arms, and shoulders weak, difficulty moving his bowels and required enemas. Unable to pass urine for two weeks, required catheterization, fever continued for a total of six to seven days
- diagnosed with blood clot the lower spinal cord and prescribed massage of the leg muscles which brought on agonizing pain. Prostrate and mildly sedated, occasionally delirious
- diagnosed with infantile paralysis instead of blood clot causing the paralysis
The Earley parents lost both their children in 3 months. I've not been able to find vax status information. He died in his sleep 2 weeks after posting that he was worried about his sister's internal bleeding. She lived another 2 months after his death and then she died. Death cert says "covid".
The longer this FRAUD goes on, the longer We the People can't fight our way out of a paper bag, the Nasties will continue to try and change history, remove knowledge, and generally do their best to try and fuck us up any way they can.
If you click the 3 dots (ellipses) to the right, you can edit your actual comment. It should come up with edit or delete. Select edit, and then you can edit the original. :)
Or perhaps it is you who are religious and stuck in your beliefs. I'm open either way. There was a pathogenic disease that seems to have gone through a society much like a cold or flu or even strep throat or chicken pox. I'm not wedded to any cultish belief system such as the obnoxious people who scream that there are no such things as viruses as they try to rudely take over conversations and force their belief system on others. Everyone is free to have their own opinions. But don't insult others calling them idiots if they don't believe your "opinions". If they deny facts, then you're justified in calling them idiots. But you cannot prove viruses don't exist as much as others cannot prove they do exist. They're a model. Like electrons screaming around a nucleus of protons and neutrons. That model might be completely wrong, but it works for much deliberation.
You're as much in a cult and unhelpful to truth-seekers as those walking around with masks on. Your arrogance, narcissism, and hubris have you all balled up in a "I'm right and everyone else is an idiot" cult of hatred. The no-virus crowd are like flat-earthers coming down from a cocaine high. Jittery and angry and you know everything. I'm not in a cult of beliefs that cause me to hate others. I haven't met a no-virus weenie yet who is civil.
You have met us, but you didn’t know it because we are civil and are willing to talk about (and listen to) the things we agree on. :) There were at least three of us (that I know of) at the event you spoke at in Keene several months ago. :) At least one of the organizers of the event is one. And I am too. And there were no doubt quite a few more. :) I could mention names, but I will leave it to them to tell you if/when they choose. ;)
Unfortunately, it is the rude ones who spout off and turn people off. I agree that it is disheartening and discouraging to continually hear things talked about as fact and truth that haven’t been scientifically proven (viruses, “covid”), but comments like those by that fellow are not helping get to the root of the issue.
The worst part to me is that to get to the bottom of it (viruses) would save so much unnecessary discussion. Billions of hours have been wasted thinking about, talking about, researching… viruses, which could have been spent on productive endeavors if people were willing to look at the very foundation of the whole issue instead of accepting it and whacking at the branches. Sadly, my son is one of them. He won’t even listen. Yet. I may have made some inroads during his recent visit, although I didn’t make a big deal out of it or continually bring the topic up.
If someone comes up with evidence for viruses, we are open to consider it, but as of right now, there is none that I know of.
Mark and Sam Bailey (doctors in New Zealand) are some of the most civil and respectful people I know of who explain this topic. Two others are David Parker and Dawn Lester from the UK (What Really Makes You Ill?).
I am convinced that your research and writing about the consequences from the latest toxic shots is very important. There is no reason to harp on our differences or to attack you or to call names. Totally out of line. I am ashamed of what I have read this man saying (I assume it’s a man). He does not represent all of us who hold this position. Please don’t judge us all by those who talk like this.
At the Weston A. Price Foundation, you will find many others who hold this position and who are polite.
Like I said, you have met others of us who appreciate the work you are doing and don’t feel the need to be aggressively antagonistic about the virus issue. The nonexistence of viruses does not negate the facts you are exposing or the work you’re doing.
N worries. I've had good conversations before with the "real" no-virus crowd. Biology just isn't my thing and I'm open to listen. I make no decisions as they're all just models to me. And some are good and some are not so good. And none are perfect.
My interaction with that guy was more for others to see what chaos agents are like in their attacks. I get it all the time on Twitter. Not so much here. I've only blocked one person here.
Hi John,
Your work is incredibly relevant and it is NEEDED. I don’t comment often (although I read your work and appreciate it a lot), this really prompted me to say something. I’m not a high level medical professional but I work as a Paramedic in the Boston area (and am in several of the well known hospitals frequently). I have been for a decade now. The alarming uptick in thrombocytopenia, heart disease, clotting disorders, cancer, pulmonary issues, autoimmune disorders, etc... is truly alarming. I work emergency 911 calls, but have a substantial amount of experience with transferring acutely (and chronically) ill patients from hospital to hospital, and sometimes to rehabs, and even hospice. I steered clear of the Covid “vaccines” (me and my family) and have paid close attention to what is truly happening concerning the repercussions and negative, sometimes (or more) deadly consequences of the untested/unproven mRNA jabs. I see it firsthand. I want to thank you for your incredible work, and I encourage and implore you to please keep informing us of these statistics. This is not only a physical war we are in, but a spiritual one at its core.
God Bless you, sir. I will be in prayer that God continues to strengthen you with every article and post you publish. This type of information (and your “opinions”) are what is needed to be disseminated. I pass it along because it’s vital in order to stop this tyranny and intentional destruction of precious life. I pray we will overcome this evil with Christ’s strength and help. I am hopeful and committed to this fight along side you and many others. Thank you!
Thanks much. I have a contact who was trying to get the call logs for 9-1-1 in a county in NY near NYC. It never happened. If only I could get those, I could really provide even more of a foundation. People are weird around Massachusetts. I've told many people about individual child deaths and young adults. They just smile and sometimes say, "Well, some are going to die, but it saved so many people." Ughh.
It’s unbelievable, John! I’m not a native of MA (although my mother is from here and my kids were born here) I am keenly aware of how misled so many are in this state. It’s as if they have genuinely bought into the Covid “narrative” (to include my own father, brother, sister, and my mother-in-law) that those who are beyond cognitive dissonance, but truly blinded by a psychology of “mass psychosis” just go along. No questions asked. I want more information on the stats you mention, desperately, but it’s going to take a seriously concerted effort on all of us who know the Truth to continue to bring it forth to the misinformed. And, in my humble opinion, taken advantage of in their mental/spiritual weakness. It’s sick. Please keep up your amazing work!!
These people need some kind of response that will blow their stupid ideas right out of their heads... I'll keep trying to find that perfect Word Bomb...
Sending you a GIANT hug-- KEEP GOING! You're fantastic, m'dear. xo xo
John, I am a nurse and I believe your assessment of the data is important.
When a doctor speaks to their patient, they pretty much use medical terms to explain the diagnosis, quickly add a few more descriptions and thats it. A patient leaves not having any idea what the doctor just said, will remember a few simple terms and maybe attempt to look up what they think they heard.
The patient really doesn't know their diagnosis, can't understand the literature...that is if they can even find it. They certainly have no idea how to look for or interpret any data associated with covid deaths, death certificates, codes, etc which might be associated with the symptoms they are experiencing.
If a patient dares to ask their doctor if their symptoms are related to the covid injection, 99% of the time the doctor will tell them it has nothing to do with their symptoms. People are conditioned to believe their doctor, the government and MSM.
I believe the information you provide is more than your opinion. You gather all the information for us and explain it in terms we can understand. It makes sense even to those who have idea about stats, data, etc!
If we don't have your expertise and ability to translate that information to us ..what will we have? More lingo, stuff that doesn't make sense and then we don't learn.
Opinion is what MSM, fauci,fda, cdc does .. they lie and never tell the truth. Your information is so much more than an opinion. And that's my 2 cents worth!
Agree 100%!! I’m not a nurse but am in hospitals as a paramedic (I do a lot of transfer work) and hear Dr’s talk to patients, as well as read patients charts all the time. As well as, obviously, I Interact with nurses the most. That’s where I usually get the truth, or at least what’s happening on a raw level. I don’t trust these young Dr’s nowadays. Even some older, more experienced ones. It pains me to say that but it’s truly how I feel. SO many people are lied to, or at minimum, not communicated well with, which is so sad. And, easy to fix, but they don’t.
You went so far to state your credentials before the opinion. From there the reader can consider it or not but removing it seems problematic as it seems someone has silenced you. JMO.
Thanks for the thought.
The editor is right because of the context you don't see in the substack article.
It doesn't belong in the section that it was in. I'm okay with it.
But thanks for the thought.
Your opinion sounds more reasonable than the garbage coming from the medical industrial complex. Too bad common sense is so rare.
Thank you John. Let's pray that the criminals are held accountable. Covid is obviously a eugenics program. David Martin makes the connection in this video:
https://twitter.com/gunthertree2/status/1702140946668810462
Peace.
I think your "opinion" makes a lot of sense. A lot.
Excellent.
Fascinating. The connection with thrombocytopenia, internal bleeding. I am witnessing this happening to a friend in her 80’s. She recently, (the past six months) has now had three episodes of passing blood. The most recent episode this past weekend. She is taken to hospital each time, til the bleeding stops and then sent home. Her doctors appear to be mystified. They cannot find a tumour or other cause for her bleeds. We are in the UK, so I doubt any type of scans were performed. My friend is an active 80 yr old, plays lawn bowls, bridge, walks each day to the shop for her newspaper. She has taken at least four if not five covid jabs. And yet not one doctor has mentioned thrombocytopenia to her. Instead they “think” she has diverticulitis. In all honesty, maybe it is best she not know, as there isn’t a thing she can do about it. The damage has been done. As I witness so many acquaintances suffering heart attacks, strokes, turbo cancers, severe vertigo, severe fatigue, unsteadiness, dementia post vaxxes, I can only shake my head in despair. The damage has been done.
Zinc levels are lower in patients with primary immune thrombocytopenia (https://doi.org/10.1007/s12011-022-03295-3) AND 15 experimental zinc(II) sites were identified on SARS-CoV-2 proteins through in silico approach. Since the Spike protein forms a trimer, a total of 9–12 zinc(II) ions could be bound to each complex.
It is my hypothesis that Zinc deprivation is the lowest common denominator of what is observed. p53 and ZAP (Zinc antiviral protein) are noth Zinc-dependent for example. If so this would lead, also in the affected tissues, to a down regulation of homocysteine (Hcy) re-methylation to methionine (Met) because both enzymes that catalyzed the reaction are zinc dependent: Met synthase (MS) or betaine Hcy methyltransferase (BHMT).
This would result in:
- A global decrease of the methylation processes thanks to:
o An increase S-adenosylhomocysteine (SAH) intracellular concentration (a well-known inhibitor of methyltransferase catalytic activities)
o And a decrease of S-adenosyl-l-methionine (SAM) intracellular concentration
- and an increase of the Hcy concentration.
As Hcy is a crux of two vital metabolic pathways: 1) the one-carbon cycle that provides C1 units for nucleotide and amino acid biosynthesis; and 2) the metabolism of sulfur-containing amino acids to regenerate Met or to provide cysteine (Cys), the short-, medium- and long-term health impacts could be huge. Among them,
1) Disturbances of lipid metabolism2: the decrease of the global methylation processes, include the conversion of phosphatidylethanolamine to phosphatidylcholine (PC). The decreased concentration of PC increases the maturation of the transcription factor sterol regulatory element-binding protein 1 (SREBP-1), thus increasing the expression of genes involved in fatty acid and triglyceride synthesis.
2) Down regulation of protection against oxidative stress3 by:
a. Downregulation of glutathione and taurine because SAM is an allosteric activator of cystathionine-beta-synthetase (CBS), one of the two-step Hcy transsulfuration to Cysteine enzymes.
b. Downregulation of SIRTUINS as they are zinc dependent. SIRT1-7 have broad action roles in the epigenetic regulation. They have the potential to change gene expression and pathways utilizing a mechanism of lysine deacetylation, by which they are able to modify histones or nonhistone proteins to alter structure and functionality. For example, SIRT1 protects organisms from the effects of oxidative stress by deacetylating a number of protein substrates. These include FoxOs, p53, poly-adenosine 5′-diphosphate (ADP), PGC1-α and the p65 subunit of NF-kappa Bis.
3) Abnormal DNA methylation4: DNA methylation plays a key role in maintaining chromosome stability and gene expression. The decreased methylation level of CpG islands promotes gene transcription and expression, and increased methylation levels of CpG islands reduce or silence gene expression. Normal methylation sites and the methylation degree are affected in the early stage of carcinogenesis, which primarily manifests as global gene hypomethylation and hypermethylation of individual sites, such as the promoter of tumor suppressor genes, which exhibit a low methylation or non-methylation state in normal cells. Moreover, a recent study5 highlighted the role of epigenetic modification of DNA methylation and pathways possibly involved in Immunoglobulin-G4-related disease pathogenesis.
4) Homocysteine modification in protein structure6: Homocysteine-containing proteins (through: protein homocysteinylation of lysine by L -Hcy-thiolactone ; participation in protein biosynthesis via S-nitroso-Hcy ; demethylation of protein Met residues to Hcy) lose their biological function and acquire cytotoxic, proinflammatory, proatherothrombotic, and proneuropathic properties (e.g.: free thiol form of Hcy is associated with endothelial dysfunction ; Hcy-thiolactone predicts acute myocardial infarction ; anti-N-Hcy-protein autoantibodies are elevated in stroke and coronary artery disease patients ; N-Hcy-protein are linked with atherosclerosis ; high Hcy is a risk factor for Alzheimer’s disease…)
1/ Andreini and colleagues “The zinc proteome of SARS-CoV-2” - Metallomics. 2022; 14(7): mfac047. doi: 10.1093/mtomcs/mfac047
2/ Masana and colleagues “Low HDL and high triglycerides predict COVID-19 severity” - Sci Rep. 2021 Mar 30;11(1):7217. doi: 10.1038/s41598-021-86747-5
3/ Kalous and colleagues “Mechanism of Sirt1 NAD+-dependent Protein Deacetylase Inhibition by Cysteine S-Nitrosation” - J Biol Chem. 2016 Dec 2; 291(49): 25398–25410. doi: 10.1074/jbc.M116.754655
4/ Li and colleagues “Blood-based DNA methylation signatures in cancer: A systematic review” -Biochim Biophys Acta Mol Basis Dis. 2023 Jan 1;1869(1):166583. doi: 10.1016/j.bbadis.2022.166583
5/ Wu and colleagues “Differential CpG DNA methylation of peripheral B cells, CD4+ T cells, and salivary gland tissues in IgG4-related disease” Arthritis Res Ther. 2023 Jan 7;25(1):4. DOI: 10.1186/s13075-022-02978-5
6/ Jakubowski “Homocysteine Modification in Protein Structure/Function and Human Disease” - Physiol Rev. 2019 Jan 1;99(1):555-604. doi: 10.1152/physrev.00003.2018
Christian
Very interesting theories about bowel necrosis and gastro bleeding. Shockingly similar to the symptoms seen in Sept/Oct 1917 on the USS Leviathan Spanish Flu "death" ship and for one of its famous very ill passengers on its transatlantic mini-plague death voyage right beforehand. Note the symptom reports which include "rare" nasal bleeding for the sick passengers who would likely have been overdosed with the new wonder drug aspirin, a blood anti-coagulant. Note the mass jabbing of the Tennessee regiment in 1917 within less than 2 weeks before boarding the "death" ship. The novel meningitis jab was being injected into US military personnel sent to the WW1 French trenches.
https://www.thehistoryreader.com/world-history/ship-of-death-the-tragic-tale-of-the-uss-leviathan/
https://www.cowhampshireblog.com/2018/09/28/100-years-ago-the-leviathan-transport-ship-of-death/ . https://megsorick.com/2018/06/20/plague-ship-leviathan/
Summer of 1918, FDR representing the US Navy Secretary returned from Europe on USS Leviathan, a massive liner converted to a troop carrier. Many died of the Spanish Flu on his 11-day westbound voyage. Roosevelt became very ill with influenza and complicating pneumonia but recovered by the time the ship landed in New York.
Leviathan's next trip eastbound to Europe:
- 3,500 troops from Tennessee "inoculated and vaccinated" within 2 weeks before before sailing. Approx 9,000 troops and 2,000 crew on board. 110 taken off the ship with Spanish Flu right before sailing, many collapsed while marching to the ship and never got onboard. All portholes closed due to fears of German U-boats; hot, stifling and overcrowded.
- Day 2 enroutete, sick bay overwhelmed with men suffering symptoms of flu. Day 3, 700 more men sick and one dead.Healthy men were confined to less well ventilated quarters. Anyone aboard sick with flu very likely would have been severely over dozed with aspirin, the standard go-to wonder drug back then for Spanish Flu. That just makes getting pneumonia much easier. Crashes immune system. FDR working for the Secretary of the Navy would likely also have received all the new whiz-bang pills like aspirin and jabs such as the new meningitis jab before sailing on that ship back from France.
- Day 4, 2,000 men sick. Official Navy report states "pools of blood from severe nasal hemorrhages [a rare Spanish Flu symptom] were scattered throughout the compartments, and the attendants were powerless to escape tracking through the mess, because of the narrow passages between the bunks." Decks covered in vomit attributed to sea sickness.
- Ship docked in Brest on October 8, 1918 with 2,000 men sick with flu and pneumonia, 80 died and been buried at sea. Another report, 280 of the ill men were too weak to get off the ship and 14 more died before the end of the day. Yet another report states 91 died aboard from Spanish Flu, hundreds taken ashore in France sick. No official count how many died there from sickness caught onboard or right before boarding. Some 1,000 of the remaining patients carried via stretcher to a base camp in a convoy that stretched four miles. From the Vermont regiment alone at least 200 died of the Spanish Flu to be buried at the French port
Look at FDR's list of symptoms when he came down with "polio" in 1921 which some now think was Guillain–Barré syndrome: https://en.wikipedia.org/wiki/Paralytic_illness_of_Franklin_D._Roosevelt
- chills, nausea, and pain in his lower back; one legs felt weak, fever, diagnosed with bad summer cold, by evening, one leg paralyzed, other become weak; Both legs paralyzed, temperature was 102 °F, pain in legs, feet and back; legs numb then painfully sensitive to touch, "so painful that he could not stand the pressure of the bedclothes, and even the movement of the breezes across his skin caused acute distress." Could not pass urine. Hands, arms, and shoulders weak, difficulty moving his bowels and required enemas. Unable to pass urine for two weeks, required catheterization, fever continued for a total of six to seven days
- diagnosed with blood clot the lower spinal cord and prescribed massage of the leg muscles which brought on agonizing pain. Prostrate and mildly sedated, occasionally delirious
- diagnosed with infantile paralysis instead of blood clot causing the paralysis
John, am I reading this right that Brianna’s brother, Dan, dies in his sleep? Do we know his jab status?
https://cheshirefamilyfuneralhome.com/daniel-dan-l-earley/
https://www.mackfamilyfh.com/obituaries/Holly-Hodgdon
The Earley parents lost both their children in 3 months. I've not been able to find vax status information. He died in his sleep 2 weeks after posting that he was worried about his sister's internal bleeding. She lived another 2 months after his death and then she died. Death cert says "covid".
The longer this FRAUD goes on, the longer We the People can't fight our way out of a paper bag, the Nasties will continue to try and change history, remove knowledge, and generally do their best to try and fuck us up any way they can.
LET'S TAKE DOWN THEIR TOWERS and go from there.
The Pfizer shot was a different formulation in 2022 which could explain the difference in thrombotic episodes.
Sorry…Holly’s brother, not Brianna’s.
If you click the 3 dots (ellipses) to the right, you can edit your actual comment. It should come up with edit or delete. Select edit, and then you can edit the original. :)
Or perhaps it is you who are religious and stuck in your beliefs. I'm open either way. There was a pathogenic disease that seems to have gone through a society much like a cold or flu or even strep throat or chicken pox. I'm not wedded to any cultish belief system such as the obnoxious people who scream that there are no such things as viruses as they try to rudely take over conversations and force their belief system on others. Everyone is free to have their own opinions. But don't insult others calling them idiots if they don't believe your "opinions". If they deny facts, then you're justified in calling them idiots. But you cannot prove viruses don't exist as much as others cannot prove they do exist. They're a model. Like electrons screaming around a nucleus of protons and neutrons. That model might be completely wrong, but it works for much deliberation.
You're as much in a cult and unhelpful to truth-seekers as those walking around with masks on. Your arrogance, narcissism, and hubris have you all balled up in a "I'm right and everyone else is an idiot" cult of hatred. The no-virus crowd are like flat-earthers coming down from a cocaine high. Jittery and angry and you know everything. I'm not in a cult of beliefs that cause me to hate others. I haven't met a no-virus weenie yet who is civil.
You have met us, but you didn’t know it because we are civil and are willing to talk about (and listen to) the things we agree on. :) There were at least three of us (that I know of) at the event you spoke at in Keene several months ago. :) At least one of the organizers of the event is one. And I am too. And there were no doubt quite a few more. :) I could mention names, but I will leave it to them to tell you if/when they choose. ;)
Unfortunately, it is the rude ones who spout off and turn people off. I agree that it is disheartening and discouraging to continually hear things talked about as fact and truth that haven’t been scientifically proven (viruses, “covid”), but comments like those by that fellow are not helping get to the root of the issue.
The worst part to me is that to get to the bottom of it (viruses) would save so much unnecessary discussion. Billions of hours have been wasted thinking about, talking about, researching… viruses, which could have been spent on productive endeavors if people were willing to look at the very foundation of the whole issue instead of accepting it and whacking at the branches. Sadly, my son is one of them. He won’t even listen. Yet. I may have made some inroads during his recent visit, although I didn’t make a big deal out of it or continually bring the topic up.
If someone comes up with evidence for viruses, we are open to consider it, but as of right now, there is none that I know of.
Mark and Sam Bailey (doctors in New Zealand) are some of the most civil and respectful people I know of who explain this topic. Two others are David Parker and Dawn Lester from the UK (What Really Makes You Ill?).
I am convinced that your research and writing about the consequences from the latest toxic shots is very important. There is no reason to harp on our differences or to attack you or to call names. Totally out of line. I am ashamed of what I have read this man saying (I assume it’s a man). He does not represent all of us who hold this position. Please don’t judge us all by those who talk like this.
At the Weston A. Price Foundation, you will find many others who hold this position and who are polite.
Like I said, you have met others of us who appreciate the work you are doing and don’t feel the need to be aggressively antagonistic about the virus issue. The nonexistence of viruses does not negate the facts you are exposing or the work you’re doing.
N worries. I've had good conversations before with the "real" no-virus crowd. Biology just isn't my thing and I'm open to listen. I make no decisions as they're all just models to me. And some are good and some are not so good. And none are perfect.
My interaction with that guy was more for others to see what chaos agents are like in their attacks. I get it all the time on Twitter. Not so much here. I've only blocked one person here.